Sven Ullrich

Feodor Lynen Postdoctoral Fellow

City/country of origin
Ludwigshafen, Germany
Hobbies
Sports, podcasts and cooking
Where for a big vacation
Adriatic Coast
What are your strong points?
Writing and presenting
What was surprising about the Suga lab
Separate buildings for students and postdocs
Original motivation towards science?
Nature, Sci-Fi and my parents
Science is
creating knowledge

学歴・職歴

2020-2024
Australian National University, Chemistry, Doctor of Philosophy
2015-2019
Heidelberg University, Pharmacy, State Examinations

発表論文

"Elucidating leader peptide–enzyme dynamics in lactazole biosynthesis using mRNA display."
E. Ang; J.S. Chang; W.-E. Huang; S. Ullrich; A.A. Vinogradov; H. Suga
J. Am. Chem. Soc., 148, (2026)
"Peptide–bismuth tricycles: maximizing stability by constraint."
L.J. Davies; P. Ghosh; S. Siryer; S. Ullrich; C. Nitsche
Chem. Eur. J., 31, e202500064 (2025)
"Synthesis, screening and validation of cysteine-reactive fragments as Chikungunya virus protease inhibitors."
J. He; H. Illingworth; S. Ullrich; P. Ghosh; J. Ton; C.J. Jackson; C. Nitsche
Bioorg. Med. Chem. Lett., 122, 130176 (2025)
"Assembling branched and macrocyclic peptides on proteins."
S. Ullrich; S. Kumaresan; M.G. Rahman; B. Panda; R. Morewood; C. Nitsche
Chem. Commun., 61, 3009-3012 (2025)
"4‐Fluoro‐2,6‐dicyanopyridine."
S. Ullrich; C. Nitsche
Encyclopedia of Reagents for Organic Synthesis, pp. 1-2 (2025)
"Synthesis of bicyclic peptides using cyanopyridine-aminothiol click chemistry."
S. Ullrich; C. Nitsche
Peptide Synthesis, pp. 13-25 (2025)
"Non-symmetric cysteine stapling in native peptides and proteins."
S. Ullrich; B. Panda; U. Somathilake; D.J. Lawes; C. Nitsche
Chem. Commun., 61, 933-936 (2025)
"Rational design and selection of next-generation cyclotide drugs using the knotted cyclic peptide scaffold MCoTI-II."
S. Ullrich; G.J.-B. Philippe; C.Y. Li; H. Suga
Austr. J. Chem., 78, CH25086 (2025)
"Shaping the future of constrained peptides and compact proteins in drug discovery."
S. Ullrich
Austr. J. Chem., 78, CH25122 (2025)
"Exploiting hydrophobic amino acid scanning to develop cyclic peptide inhibitors of the SARS‐CoV‐2 main protease with antiviral activity."
K. Harrison; P.W. Carlos; S. Ullrich; A. Aggarwal; J. Johansen‐Leete; V.M. Sasi; I. Barter; J.W.C. Maxwell; M.J. Bedding; M. Larance; S. Turville; A. Norman; C.J. Jackson; C. Nitsche; R.J. Payne
Chem. Eur. J., 30, e202401606 (2024)
"Synthesis and stability studies of constrained peptide–antimony bicycles."
S. Ullrich; P. Ghosh; M. Shang; S. Siryer; S. Kumaresan; B. Panda; L.J. Davies; U. Somathilake; A.P. Patel; C. Nitsche
Austr. J. Chem., 77, CH24094 (2024)
"A RaPID response to SARS‐CoV‐2."
S. Ullrich; C. Nitsche
Isr. J. Chem., e202300170 (2024)
"Bicyclic peptides: paving the road for therapeutics of the future."
S. Ullrich; C. Nitsche
Pept. Sci., 116, e24326 (2024)
"Phage-encoded bismuth bicycles enable instant access to targeted bioactive peptides."
S. Ullrich; U. Somathilake; M. Shang; C. Nitsche
Commun. Chem., 7, 143 (2024)
"Probing ligand binding sites on large proteins by nuclear magnetic resonance spectroscopy of genetically encoded non-canonical amino acids."
K.B. Ekanayake; M.C. Mahawaththa; H. Qianzhu; E.H. Abdelkader; J. George; S. Ullrich; R.B. Murphy; S.E. Fry; J. Johansen-Leete; R.J. Payne; C. Nitsche; T. Huber; G. Otting
J. Med. Chem., 66, 5289-5304 (2023)
"Antiviral cyclic peptides targeting the main protease of SARS-CoV-2."
J. Johansen-Leete; S. Ullrich; S.E. Fry; R. Frkic; M.J. Bedding; A. Aggarwal; A.S. Ashhurst; K.B. Ekanayake; M.C. Mahawaththa; V.M. Sasi; S. Luedtke; D.J. Ford; A.J. O'Donoghue; T. Passioura; M. Larance; G. Otting; S. Turville; C.J. Jackson; C. Nitsche; R.J. Payne
Chem. Sci., 13, 3826-3836 (2022)
"Site-selective generation of lanthanoid binding sites on proteins using 4-fluoro-2,6-dicyanopyridine."
S. Mekkattu Tharayil; M.C. Mahawaththa; A. Feintuch; A. Maleckis; S. Ullrich; R. Morewood; M.J. Maxwell; T. Huber; C. Nitsche; D. Goldfarb; G. Otting
Magn. Reson., 3, 169-182 (2022)
"Predicting antiviral resistance mutations in SARS-CoV-2 main protease with computational and experimental screening."
V.M. Sasi; S. Ullrich; J. Ton; S.E. Fry; J. Johansen-Leete; R.J. Payne; C. Nitsche; C.J. Jackson
Biochemistry, 61, 2495-2505 (2022)
"Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir."
S. Ullrich; K.B. Ekanayake; G. Otting; C. Nitsche
Bioorg. Med. Chem. Lett., 62, 128629 (2022)
"Biocompatible and selective generation of bicyclic peptides."
S. Ullrich; J. George; A.E. Coram; R. Morewood; C. Nitsche
Angew. Chem. Int. Ed., 61, e202208400 (2022)
"SARS‐CoV‐2 papain‐like protease: structure, function and inhibition."
S. Ullrich; C. Nitsche
ChemBioChem, 23, e202200327 (2022)
"Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors."
S. Ullrich; V.M. Sasi; M.C. Mahawaththa; K.B. Ekanayake; R. Morewood; J. George; L. Shuttleworth; X. Zhang; C. Whitefield; G. Otting; C. Jackson; C. Nitsche
Bioorg. Med. Chem. Lett., 50, 128333 (2021)
"The SARS-CoV-2 main protease as drug target."
S. Ullrich; C. Nitsche
Bioorg. Med. Chem. Lett., 30, 127377 (2020)

連絡先

    • E-mail… sullrich@(@以下はg.ecc.u-tokyo.ac.jp)