菅研究室｜論文発表

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2025年

"A versatile method of ribosomal synthesis of peptides containing long chain fatty acids at the N-terminus.": H. Murakami; N. Terasaka; H. Aikawa; H. Suga; Bull Chem Soc Jpn, appeared online https://doi.org/10.1093/bulcsj/uoaf027 (2025)
"Diversity Scale of Library Matters: Impact of mRNA Library Diversity Scales on the Discovery of Macrocyclic Peptides Targeting a Protein by the RaPID System.": J. Zhao; Y. Li; N. Terasaka; H. Aikawa; H. Suga; ACS Cent Sci, 11, 431-440 (2025)

2024年

"Illuminating Substrate Preferences of Promiscuous F(420)H(2)-Dependent Dehydroamino Acid Reductases with 4-Track mRNA Display.": A.A. Vinogradov; G. Bashiri; H. Suga; J Am Chem Soc, 146, 31124-31136 (2024)
"Selective pH-Responsive Conjugation between a Pair of De Novo Discovered Peptides.": Y. Ohno; A.A. Vinogradov; H. Suga; J Am Chem Soc, 146, 29429-29440 (2024)
"Reprogramming the genetic code with flexizymes.": T. Katoh; H. Suga; Nat Rev Chem, 8, 879-892 (2024)
"Selection of Nucleotide-Encoded Mass Libraries of Macrocyclic Peptides for Inaccessible Drug Targets.": K. Colas; D. Bindl; H. Suga; Chem Rev, 124, 12213-12241 (2024)
"Exocyclic and Linker Editing of Lys63-linked Ubiquitin Chains Modulators Specifically Inhibits Non-homologous End-joining Repair.": A. Saha; L.A. Bishara; Y. Saed; G.B. Vamisetti; S. Mandal; H. Suga; N. Ayoub; A. Brik; Angew Chem Int Ed Engl, e202409012 (2024)
"A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model.": N.M. Rojas-Chaverra; R. Imamura; H. Sato; T. Passioura; E. Mihara; T. Nishimura; J. Takagi; H. Suga; K. Matsumoto; K. Sakai; iScience, 27, 110426 (2024)
"Mirror-Image Random Nonstandard Peptide Integrated Discovery (MI-RaPID) Technology Yields Highly Stable and Selective Macrocyclic Peptide Inhibitors for Matrix Metallopeptidase 7.": N. Metanis; H. Ghareeb; C.Y. Li; A. Shenoy; N. Rotenberg; J.M. Shifman; T. Katoh; I. Sagi; H. Suga; Angew Chem Int Ed Engl, e202414256 (2024)
"Mixed Stereochemistry Macrocycle Acts as a Helix-Stabilizing Peptide N-Cap.": F. Hink; J. Aduriz-Arrizabalaga; X. Lopez; H. Suga; D. De Sancho; J.M. Rogers; J Am Chem Soc, 146, 24348-24357 (2024)
"Oxidation-guided and collision-induced linearization assists de novo sequencing of thioether macrocyclic peptides.": A. Hayashi; Y. Goto; Y. Saito; H. Suga; J. Morimoto; S. Sando; Chem Commun (Camb), 60, 9436-9439 (2024)
"A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides.": A.A. Vinogradov; Y. Zhang; K. Hamada; S. Kobayashi; K. Ogata; T. Sengoku; Y. Goto; H. Suga; J Am Chem Soc, 146, 8058-8070 (2024)
"Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling.": K. Simelis; H. Sarac; E. Salah; K. Nishio; T.E. McAllister; T.P. Corner; A. Tumber; R. Belle; C.J. Schofield; H. Suga; A. Kawamura; Bioorg Med Chem, 99, 117597 (2024)
"Engineering tRNAs for the Ribosomal Translation of Non-proteinogenic Monomers.": M. Sigal; S. Matsumoto; A. Beattie; T. Katoh; H. Suga; Chem Rev, 124, 6444-6500 (2024)
"Cheminformatics-Guided Cell-Free Exploration of Peptide Natural Products.": J.M. Pelton; J.E. Hochuli; P.W. Sadecki; T. Katoh; H. Suga; L.M. Hicks; E.N. Muratov; A. Tropsha; A.A. Bowers; J Am Chem Soc, 146, 8016-8030 (2024)
"Cyclic beta(2,3)-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease.": T. Miura; T.R. Malla; L. Brewitz; A. Tumber; E. Salah; K.J. Lee; N. Terasaka; C.D. Owen; C. Strain-Damerell; P. Lukacik; M.A. Walsh; A. Kawamura; C.J. Schofield; T. Katoh; H. Suga; Bull Chem Soc Jpn, 97, uoae018 (2024)
"In Vitro Selection of Macrocyclic l-alpha/d-alpha/beta/gamma-Hybrid Peptides Targeting IFN-gamma/IFNGR1 Protein-Protein Interaction.": T. Miura; K.J. Lee; T. Katoh; H. Suga; J Am Chem Soc, (2024)
"An anticodon-sensing T-boxzyme generates the elongator nonproteinogenic aminoacyl-tRNA in situ of a custom-made translation system for incorporation.": W. Lu; N. Terasaka; Y. Sakaguchi; T. Suzuki; T. Suzuki; H. Suga; Nucleic Acids Res, 52, 3938-3949 (2024)
"Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides.": H.R. King; M. Bycroft; T.B. Nguyen; G. Kelly; A.A. Vinogradov; P.J.E. Rowling; K. Stott; D.B. Ascher; H. Suga; L.S. Itzhaki; K. Artavanis-Tsakonas; Proc Natl Acad Sci U S A, 121, e2322923121 (2024)
"Fine-tuning the tRNA anticodon arm for multiple/consecutive incorporations of beta-amino acids and analogs.": T. Katoh; H. Suga; Nucleic Acids Res, 52, 6586-6595 (2024)
"De Novo Discovery of Pseudo-Natural Prenylated Macrocyclic Peptide Ligands.": S. Inoue; D.T. Nguyen; K. Hamada; R. Okuma; C. Okada; M. Okada; I. Abe; T. Sengoku; Y. Goto; H. Suga; Angew Chem Int Ed Engl, e202409973 (2024)
"Protein Grafting Techniques: From Peptide Epitopes to Lasso-Grafted Neobiologics.": M. Imai; K. Colas; H. Suga; Chempluschem, e202400152 (2024)
"PlexinB1 inactivation reprograms immune cells in the tumor microenvironment, inhibiting breast cancer growth and metastatic dissemination.": G. Franzolin; S. Brundu; C.F. Cojocaru; A. Curatolo; M. Ponzo; R. Mastrantonio; E. Mihara; A. Kumanogoh; H. Suga; J. Takagi; L. Tamagnone; E. Giraudo; Cancer Immunol Res, (2024)

2023年

"Switching Prenyl Donor Specificities of Cyanobactin Prenyltransferases.": Y. Zhang; K. Hamada; M. Satake; T. Sengoku; Y. Goto; H. Suga; J Am Chem Soc, 145, 23893-23898 (2023)
"mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome.": J.K.K. Low; K. Patel; N. Jones; P. Solomon; A. Norman; J.W.C. Maxwell; P. Pachl; J.M. Matthews; R.J. Payne; T. Passioura; H. Suga; L.J. Walport; J.P. Mackay; J Biol Chem, 299, 105482 (2023)
"Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation.": B. Lemma; D. Zhang; G.B. Vamisetti; B.G. Wentz; H. Suga; A. Brik; J. Lubkowski; D. Fushman; Nat Commun, 14, 7212 (2023)
"A comprehensive analysis of translational misdecoding pattern and its implication on genetic code evolution.": T. Katoh; H. Suga; Nucleic Acids Res, 51, 10642-10652 (2023)
"Display Selection of a Hybrid Foldamer-Peptide Macrocycle.": S. Dengler; R.T. Howard; V. Morozov; C. Tsiamantas; W.E. Huang; Z. Liu; C. Dobrzanski; V. Pophristic; S. Brameyer; C. Douat; H. Suga; I. Huc; Angew Chem Int Ed Engl, 62, e202308408 (2023)
"Macrocyclic Peptides Closed by a Thioether-Bipyridyl Unit That Grants Cell Membrane Permeability.": H. Chen; T. Katoh; H. Suga; ACS Bio Med Chem Au, 3, 429-437 (2023)
"Deep Learning-Driven Library Design for the De Novo Discovery of Bioactive Thiopeptides.": J.S. Chang; A.A. Vinogradov; Y. Zhang; Y. Goto; H. Suga; ACS Cent Sci, 9, 2150-2160 (2023)
"Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes.": A. Saha; H. Suga; A. Brik; Acc Chem Res, 56, 1953-1965 (2023)
"In vitro selection of macrocyclic peptide inhibitors containing cyclic gamma(2,4)-amino acids targeting the SARS-CoV-2 main protease.": T. Miura; T.R. Malla; C.D. Owen; A. Tumber; L. Brewitz; M.A. McDonough; E. Salah; N. Terasaka; T. Katoh; P. Lukacik; C. Strain-Damerell; H. Mikolajek; M.A. Walsh; A. Kawamura; C.J. Schofield; H. Suga; Nat Chem, 15, 998-1005 (2023)
"Structural basis of tRNAPro acceptor stem recognition by a bacterial trans-editing domain.": X. Ma; M. Bakhtina; I. Shulgina; W.A. Cantara; A.B. Kuzmishin Nagy; Y. Goto; H. Suga; M.P. Foster; K. Musier-Forsyth; Nucleic Acids Res, 51, 3988-3999 (2023)
"MET-Activating Ubiquitin Multimers.": N. Kawakami; H. Sato; N. Terasaka; K. Matsumoto; H. Suga; Angew Chem Int Ed Engl, e202307157 (2023)
"Translation initiation with exotic amino acids using EF-P-responsive artificial initiator tRNA.": T. Katoh; H. Suga; Nucleic Acids Res, (2023)
"Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.": C. Franck; K. Patel; L.J. Walport; M. Christie; A. Norman; T. Passioura; H. Suga; R.J. Payne; J.P. Mackay; Structure, 31, 912-923 e914 (2023)
"Discovery, biochemical characterization, and bioengineering of cyanobactin prenyltransferases.": Y. Zhang; Y. Goto; H. Suga; Trends Biochem Sci, 48, 360-374 (2023)
"Two-Chain Mature Hepatocyte Growth Factor-Specific Positron Emission Tomography Imaging in Tumors Using (64)Cu-Labeled HiP-8, a Nonstandard Macrocyclic Peptide Probe.": S. Warashina; H. Sato; M. Zouda; M. Takahashi; Y. Wada; T. Passioura; H. Suga; Y. Watanabe; K. Matsumoto; H. Mukai; Mol Pharm, 20, 2029-2038 (2023)
"Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions.": K. Sakai; N. Sugano-Nakamura; E. Mihara; N.M. Rojas-Chaverra; S. Watanabe; H. Sato; R. Imamura; D.C. Voon; I. Sakai; C. Yamasaki; C. Tateno; M. Shibata; H. Suga; J. Takagi; K. Matsumoto; Nat Biomed Eng, 7, 164-176 (2023)
"A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation.": H.L. Pietz; A. Abbas; Z.L. Johnson; M.L. Oldham; H. Suga; J. Chen; Proc Natl Acad Sci U S A, 120, e2220012120 (2023)
"Label-free quantification of passive membrane permeability of cyclic peptides across lipid bilayers: penetration speed of cyclosporin A across lipid bilayers.": T. Ono; K.V. Tabata; Y. Goto; Y. Saito; H. Suga; H. Noji; J. Morimoto; S. Sando; Chem Sci, 14, 345-349 (2023)
"Drop-off-reinitiation at the amino termini of nascent peptides and its regulation by IF3, EF-G, and RRF.": T. Katoh; H. Suga; RNA, 29, 663-674 (2023)
"Ribosomal incorporation of negatively charged d-alpha- and N-methyl-l-alpha-amino acids enhanced by EF-Sep.": T. Katoh; H. Suga; Philos Trans R Soc Lond B Biol Sci, 378, 20220038 (2023)
"A RaPID Macrocyclic Peptide That Inhibits the Formation of alpha-Synuclein Amyloid Fibrils.": T. Ikenoue; M. Oono; M. So; H. Yamakado; T. Arata; R. Takahashi; Y. Kawata; H. Suga; Chembiochem, e202300320 (2023)
"Ribosomal Synthesis of Peptides Bearing Noncanonical Backbone Structures via Chemical Posttranslational Modifications.": Y. Goto; H. Suga; Methods Mol Biol, 2670, 255-266 (2023)
"Potent De Novo Macrocyclic Peptides That Inhibit O-GlcNAc Transferase through an Allosteric Mechanism.": M.G. Alteen; H. Peacock; R.W. Meek; J.A. Busmann; S. Zhu; G.J. Davies; H. Suga; D.J. Vocadlo; Angew Chem Int Ed Engl, 62, e202215671 (2023)

2022年

"Post-translational backbone-acyl shift yields natural product-like peptides bearing hydroxyhydrocarbon units.": T. Kuroda; Y. Huang; S. Nishio; Y. Goto; H. Suga; Nature chemistry, (2022)
"De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors.": A.A. Vinogradov; Y. Zhang; K. Hamada; J.S. Chang; C. Okada; H. Nishimura; N. Terasaka; Y. Goto; K. Ogata; T. Sengoku; H. Onaka; H. Suga; J Am Chem Soc, 144, 20332-20341 (2022)
"Solid-Phase-Based Synthesis of Lactazole-Like Thiopeptides.": Y. Zhang; A.A. Vinogradov; J.S. Chang; Y. Goto; H. Suga; Org Lett, 24, 7894-7899 (2022)
"Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair.": G.B. Vamisetti; A. Saha; Y.J. Huang; R. Vanjari; G. Mann; J. Gutbrod; N. Ayoub; H. Suga; A. Brik; Nature communications, 13, 6174 (2022)
"State-selective modulation of heterotrimeric Galphas signaling with macrocyclic peptides.": S.A. Dai; Q. Hu; R. Gao; E.E. Blythe; K.K. Touhara; H. Peacock; Z. Zhang; M. von Zastrow; H. Suga; K.M. Shokat; Cell, (2022)
"In Vitro Selection of Macrocyclic alpha/beta(3)-Peptides against Human EGFR.": R. Wakabayashi; M. Kawai; T. Katoh; H. Suga; J Am Chem Soc, (2022)
"LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates.": Y.C. Zhang; K. Hamada; D.T. Nguyen; S. Inoue; M. Satake; S. Kobayashi; C. Okada; K. Ogata; M. Okada; T. Sengoku; Y. Goto; H. Suga; Nat Catal, 5, 682-+ (2022)
"In Vitro Selection of Thioether-Closed Macrocyclic Peptide Ligands by Means of the RaPID System.": T. Katoh; Y. Goto; H. Suga; Methods Mol Biol, 2371, 247-259 (2022)
"De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function.": N. Sugano-Nakamura; K. Matoba; M. Hirose; N.K. Bashiruddin; Y. Matsunaga; K. Yamashita; K. Hirata; M. Yamamoto; T. Arimori; H. Suga; J. Takagi; Structure, (2022)
"Inner residues of macrothiolactone in autoinducer peptides I/IV circumvent spontaneous S-to-O acyl transfer to the upstream serine residue.": M. Nagano; S. Ishida; H. Suga; RSC Chem Biol, 3, 295-300 (2022)
"Phosphine addition to dehydroalanine for peptide modification.": M. Liu; M. Sovrovic; H. Suga; S.A.K. Jongkees; Org Biomol Chem, 20, 3081-3085 (2022)
"In Vitro Genetic Code Reprogramming for the Expansion of Usable Noncanonical Amino Acids.": T. Katoh; H. Suga; Annual review of biochemistry, 91, 221-243 (2022)
"Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases.": R.H .P. van Neer; P.K. Dranchak; L. Liu; M. Aitha; B. Queme; H. Kimura; T. Katoh; K.P. Battaile; S. Lovell; J. Inglese; H. Suga; ACS Chem Biol, 17, 2284-2295 (2022)
"A context-dependent and disordered ubiquitin-binding motif.": J.E. Dreier; A. Prestel; J.M. Martins; S.S. Brondum; O. Nielsen; A.E. Garbers; H. Suga; W. Boomsma; J.M. Rogers; R. Hartmann-Petersen; B.B. Kragelund; Cell Mol Life Sci, 79, 484 (2022)
"Accurate Models of Substrate Preferences of Post-Translational Modification Enzymes from a Combination of mRNA Display and Deep Learning.": A.A. Vinogradov; J.S. Chang; H. Onaka; Y. Goto; H. Suga; ACS Cent Sci, 8, 814-824 (2022)
"Drop-off-reinitiation triggered by EF-G-driven mistranslocation and its alleviation by EF-P.": K. Tajima; T. Katoh; H. Suga; Nucleic Acids Res, 50, 2736-2753 (2022)
"Potent macrocycle inhibitors of the human SAGA deubiquitinating module.": M. Morgan; T. Ikenoue; H. Suga; C. Wolberger; Cell Chem Biol, 29, 544-554 e544 (2022)
"In Vitro Selection of Foldamer-Like Macrocyclic Peptides Containing 2-Aminobenzoic Acid and 3-Aminothiophene-2-Carboxylic Acid.": T. Katoh; H. Suga; J Am Chem Soc, 144, 2069-2072 (2022)

2021年

"Macrocyclic Peptide-Conjugated Tip for Fast and Selective Molecular Recognition Imaging by High-Speed Atomic Force Microscopy.": L. Puppulin; D. Kanayama; N. Terasaka; K. Sakai; N. Kodera; K. Umeda; A. Sumino; A. Marchesi; W. Weilin; H. Tanaka; T. Fukuma; H. Suga; K. Matsumoto; M. Shibata; ACS applied materials & interfaces, 13, 54817-54829 (2021)
"Consecutive Ribosomal Incorporation of alpha-Aminoxy/alpha-Hydrazino Acids with l/d-Configurations into Nascent Peptide Chains.": T. Katoh; H. Suga; J Am Chem Soc, 143, 18844-18848 (2021)
"An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human beta-Factor XIIa in a Cyclotide Scaffold.": W. Liu; S.J. de Veer; Y.H. Huang; T. Sengoku; C. Okada; K. Ogata; C.N. Zdenek; B.G. Fry; J.E. Swedberg; T. Passioura; D.J. Craik; H. Suga; J Am Chem Soc, 143, 18481-18489 (2021)
"Discovery and Development of Cyclic Peptide Inhibitors of CIB1.": V.A. Haberman; S.R. Fleming; T.M. Leisner; A.C. Puhl; E. Feng; L. Xie; X. Chen; Y. Goto; H. Suga; L.V. Parise; D. Kireev; K.H. Pearce; A.A. Bowers; Acs Med Chem Lett, 12, 1832-1839 (2021)
"De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist.": Y. Komatsu; N. Terasaka; K. Sakai; E. Mihara; R. Wakabayashi; K. Matsumoto; D. Hilvert; J. Takagi; H. Suga; iScience, 24, 103302 (2021)
"The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides.": Y. Goto; H. Suga; Acc. Chem. Res., 54, 3604-3617 (2021)
"Site-Specific Nonenzymatic Peptide S/O-Glutamylation Reveals the Extent of Substrate Promiscuity in Glutamate Elimination Domains.": A.A. Vinogradov; M. Nagano; Y. Goto; H. Suga; J Am Chem Soc, 143, 13358-13369 (2021)
"De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition.": E. Stefan; R. Obexer; S. Hofmann; K. Vu Huu; Y. Huang; N. Morgner; H. Suga; R. Tampe; eLife, 10, (2021)
"Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming.": D.J. Ford; N.M. Duggan; S.E. Fry; J. Ripoll-Rozada; S.M. Agten; W.Y. Liu; L. Corcilius; T.M. Hackeng; R. van Oerle; H.M.H. Spronk; A.S. Ashhurst; V.M. Sasi; J.A. Kaczmarski; C.J. Jackson; P.J.B. Pereira; T. Passioura; H. Suga; R.J. Payne; Journal of medicinal chemistry, 64, 7853-7876 (2021)
"Uniform affinity-tuning of N-methyl-aminoacyl-tRNAs to EF-Tu enhances their multiple incorporation.": Y. Iwane; H. Kimura; T. Katoh; H. Suga; Nucleic Acids Res, (2021)
"Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models.": M. Saito; Y. Itoh; F. Yasui; T. Munakata; D. Yamane; M. Ozawa; R. Ito; T. Katoh; H. Ishigaki; M. Nakayama; S. Shichinohe; K. Yamaji; N. Yamamoto; A. Ikejiri; T. Honda; T. Sanada; Y. Sakoda; H. Kida; T.Q.M. Le; Y. Kawaoka; K. Ogasawara; K. Tsukiyama-Kohara; H. Suga; M. Kohara; Nature communications, 12, 2654 (2021)
"The Development of a Fluorescence-Based Competitive Assay Enabled the Discovery of Dimeric Cyclic Peptide Modulators of Ubiquitin Chains.": G.B. Vamisetti; R. Meledin; M. Nawatha; H. Suga; A. Brik; Angewandte Chemie, 60, 7018-7023 (2021)
"Discovery of De Novo Macrocyclic Peptides by Messenger RNA Display.": H. Peacock; H. Suga; Trends in pharmacological sciences, (2021)
"Targeting of extracellular protein-protein interactions with macrocyclic peptides.": S. Taguchi; H. Suga; Current opinion in chemical biology, 62, 82-89 (2021)
"Structure-activity relationship of ipglycermide binding to phosphoglycerate mutases.": M. Wiedmann; P.K. Dranchak; M. Aitha; B. Queme; C.D. Collmus; M.M. Kashipathy; L. Kanter; L. Lamy; J.M. Rogers; D. Tao; K.P. Battaile; G. Rai; S. Lovell; H. Suga; J. Inglese; J Biol Chem, 100628 (2021)
"In Vitro Selection of Macrocyclic d/l-Hybrid Peptides against Human EGFR.": S. Imanishi; T. Katoh; Y. Yin; M. Yamada; M. Kawai; H. Suga; J Am Chem Soc, (2021)
"One-Pot In Vitro Ribosomal Synthesis of Macrocyclic Depsipeptides.": M. Nagano; Y. Huang; R. Obexer; H. Suga; J Am Chem Soc, 143, 4741-4750 (2021)
"Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins.": E. Mihara; S. Watanabe; N.K. Bashiruddin; N. Nakamura; K. Matoba; Y. Sano; R. Maini; Y. Yin; K. Sakai; T. Arimori; K. Matsumoto; H. Suga; J. Takagi; Nature communications, 12, 1543 (2021)
"Posttranslational chemical installation of azoles into translated peptides.": H. Tsutsumi; T. Kuroda; H. Kimura; Y. Goto; H. Suga; Nature communications, 12, 696 (2021)
"In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides.": J.M. Rogers; M. Nawatha; B. Lemma; G.B. Vamisetti; I. Livneh; U. Barash; I. Vlodavsky; A. Ciechanover; D. Fushman; H. Suga; A. Brik; RSC Chem Biol, (2021)

2020年

"Human trans-editing enzyme displays tRNA acceptor-stem specificity and relaxed amino acid selectivity.": O. Vargas-Rodriguez; M. Bakhtina; D. McGowan; J. Abid; Y. Goto; H. Suga; K. Musier-Forsyth; J Biol Chem, 295, 16180-16190 (2020)
"Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming.": A.A. Vinogradov; H. Suga; Cell chemical biology, 27, 1032-1051 (2020)
"Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation.": N.K. Bashiruddin; M. Hayashi; M. Nagano; Y. Wu; Y. Matsunaga; J. Takagi; T. Nakashima; H. Suga; Proc Natl Acad Sci U S A, 117, 31070-31077 (2020)
"Accurate Broadcasting of Substrate Fitness for Lactazole Biosynthetic Pathway from Reactivity-Profiling mRNA Display.": A.A. Vinogradov; E. Nagai; J.S. Chang; K. Narumi; H. Onaka; Y. Goto; H. Suga; J Am Chem Soc, (2020)
"Cyclic peptides can engage a single binding pocket through highly divergent modes.": K. Patel; L.J. Walport; J.L. Walshe; P.D. Solomon; J.K.K. Low; D.H. Tran; K.S. Mouradian; A.P.G. Silva; L. Wilkinson-White; A. Norman; C. Franck; J.M. Matthews; J.M. Guss; R.J. Payne; T. Passioura; H. Suga; J.P. Mackay; Proc Natl Acad Sci U S A, 117, 26728-26738 (2020)
"Discovery of quorum quenchers targeting the membrane-embedded sensor domain of theStaphylococcus aureusreceptor histidine kinase, AgrC.": Q. Xie; M.M. Wiedmann; A. Zhao; I.R. Pagan; R.P. Novick; H. Suga; T.W. Muir; Chemical communications, 56, 11223-11226 (2020)
"Ribosomal Elongation of Aminobenzoic Acid Derivatives.": T. Katoh; H. Suga; J Am Chem Soc, 142, 16518-16522 (2020)
"GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.": Z. Zhang; R. Gao; Q. Hu; H. Peacock; D.M. Peacock; S. Dai; K.M. SHokat; H. Suga; ACS Cent. Sci., (2020)
"Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic beta-amino acids.": T. Katoh; T. Sengoku; K. Hirata; K. Ogata; H. Suga; Nature chemistry, (2020)
"Promiscuous Enzymes Cooperate at the Substrate Level En Route to Lactazole A.": A.A. Vinogradov; M. Shimomura; N. Kano; Y. Goto; H. Onaka; H. Suga; J Am Chem Soc, 142, 13886-13897 (2020)
"A Macrocyclic Peptide Library with a Structurally Constrained Cyclopropane-containing Building Block Leads to Thiol-independent Inhibitors of Phosphoglycerate Mutase.": R. Okuma; T. Kuwahara; T. Yoshikane; M. Watanabe; P. Dranchak; J. Inglese; S. Shuto; Y. Goto; H. Suga; Chemistry, an Asian journal, (2020)
"Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPalpha Interaction as a Potential Cancer Immunotherapy.": D. Hazama; Y. Yin; Y. Murata; M. Matsuda; T. Okamoto; D. Tanaka; N. Terasaka; J. Zhao; M. Sakamoto; Y. Kakuchi; Y. Saito; T. Kotani; Y. Nishimura; A. Nakagawa; H. Suga; T. Matozaki; Cell chemical biology, 27, 1181-1191 e1187 (2020)
"Minimal lactazole scaffold for in vitro thiopeptide bioengineering.": A.A. Vinogradov; M. Shimomura; Y. Goto; T. Ozaki; S. Asamizu; Y. Sugai; H. Suga; H. Onaka; Nat Commun, 11, 2272 (2020)
"Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display.": J. Johansen-Leete; T. Passioura; S. Foster; R.P. Bhusal; D. Ford; M. Liu; S.A.K. Jongkees; H. Suga; M.J. Stone; R.J. Payne; J Am Chem Soc, (2020)
"Design, Synthesis, and Conformation-Activity Study of Unnatural Bridged Bicyclic Depsipeptides as Highly Potent Hypoxia Inducible Factor-1 Inhibitors and Antitumor Agents.": K. Koike; M. Nagano; M. Ebihara; T. Hirayama; M. Tsuji; H. Suga; H. Nagasawa; J Med Chem, 63, 4022-4046 (2020)
"Initiating ribosomal peptide synthesis with exotic building blocks.": C. Tsiamantas; J.M. Rogers; H. Suga; Chem Commun, 56, 4265-4272 (2020)
"Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a.": M.E. Otero-Ramirez; K. Matoba; E. Mihara; T. Passioura; J. Takagi; H. Suga; RSC Chem Biol, 1, 26-34 (2020)
"An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch.": S. Ishida; N. Terasaka; T. Katoh; H. Suga; Nat Chem Biol, (2020)
"Ribosomal Elongation of Cyclic γ-Amino Acids using a Reprogrammed Genetic Code.": T. Katoh; H. Suga; J Am Chem Soc, 142, 4965-4969 (2020)
"Exploring the Post-Translational Enzymology of PaaA by mRNA Display.": S.R. Fleming; P.M. Himes; S.V. Ghodge; Y. Goto; H. Suga; A.A. Bowers; J Am Chem Soc, 142, 5024-5028 (2020)
"Affinity Maturation of Macrocyclic Peptide Modulators of Lys48-linked Diubiquitin by a Twofold Strategy.": H. Suga; A. Brik; Y. Huang; M. Nawatha; Chem Eur J, (2020)
"Improved Stability of siRNA-Loaded Lipid Nanoparticles Prepared with a PEG-Monoacyl Fatty Acid Facilitates Ligand-Mediated siRNA Delivery.": Y. Sakurai; W. Mizumura; K. Ito; K. Iwasaki; T. Katoh; Y. Goto; H. Suga; H. Harashima; Mol Pharm, 17, 1397-1404 (2020)
"Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages.": C. Tsiamantas; S. Kwon; J.M. Rogers; C. Douat; I. Huc; H. Suga; Angew Chem Int Edit, 59, 4860-4864 (2020)

2019年

"Ribosomal Formation of Thioamide Bonds in Polypeptide Synthesis.": R. Maini; H. Kimura; R. Takatsuji; T. Katoh; Y. Goto; H. Suga; J Am Chem Soc, 141, 20004-20008 (2019)
"De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor.": Y. Yin; N. Ochi; T.W. Craven; D. Baker; N. Takigawa; H. Suga; J Am Chem Soc, 141, 19193-19197 (2019)
"Chemoenzymatic Posttranslational Modification Reactions for the Synthesis of Ψ[CH2NH]-Containing Peptides.": Y. Kato; T. Kuroda; Y. Huang; R. Ohta; Y. Goto; H. Suga; Angew Chem Int Edit, 59, 684-688 (2019)
"In Vitro Biosynthesis of Peptides Containing Exotic Azoline Analogues.": Y. Goto; H. Suga; Chembiochem, 21, 84-87 (2020)
"Generation of non-standard macrocyclic peptides specifically binding TSC-22 homologous gene-1.": S.T.P. Tran; C.J. Hipolito; H. Suzuki; R. Xie; H.D. Kim Tuyen; P.T. Dijke; N. Terasaka; Y. Goto; H. Suga; M. Kato; Biochem Biophys Res Commun, 516, 445-450 (2019)
"De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains.": M. Nawatha; J.M. Rogers; S.M. Bonn; I. Livneh; B. Lemma; S.M. Mali; G.B. Vamisetti; H. Sun; B. Bercovich; Y. Huang; A. Ciechanover; D. Fushman; H. Suga; A. Brik; Nature chemistry, 11, 644-652 (2019)
"A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display.": H. Hirose; T. Hideshima; T. Katoh; H. Suga; Chembiochem, 20, 2089-2100 (2019)
"Optimizing aromatic oligoamide foldamer side-chains for ribosomal translation initiation.": C. Tsiamantas; S. Kwon; C. Douat; I. Huc; H. Suga; Chemical communications, 55, 7366-7369 (2019)
"Discovery of Functional Macrocyclic Peptides by Means of the RaPID System.": C. Tsiamantas; M.E. Otero-Ramirez; H. Suga; Methods Mol Biol, 2001, 299-315 (2019)
"Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.": K. Sakai; T. Passioura; H. Sato; K. Ito; H. Furuhashi; M. Umitsu; J. Takagi; Y. Kato; H. Mukai; S. Warashina; M. Zouda; Y. Watanabe; S. Yano; M. Shibata; H. Suga; K. Matsumoto; Nature chemical biology, 15, 598-606 (2019)
"Exploring of minimal RNA substrate of flexizymes.": T. Fujino; T. Kondo; H. Suga; H. Murakami; Chembiochem, (2019)
"Engineering Translation Components Improve Incorporation of Exotic Amino Acids.": T. Katoh; H. Suga; International journal of molecular sciences, 20, (2019)
"Flexizyme-catalyzed synthesis of 3'-aminoacyl-NH-tRNAs.": T. Katoh; H. Suga; Nucleic Acids Res, 47, e54 (2019)
"Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges.": A.A. Vinogradov; Y. Yin; H. Suga; J Am Chem Soc, 141, 4167-4181 (2019)
"Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation.": Y. Yin; Q. Fei; W. Liu; Z. Li; H. Suga; C. Wu; Angewandte Chemie, 58, 4880-4885 (2019)
"Ribosomal Synthesis of Backbone-Cyclic Peptides Compatible with In Vitro Display.": R. Takatsuji; K. Shinbara; T. Katoh; Y. Goto; T. Passioura; R. Yajima; Y. Komatsu; H. Suga; J Am Chem Soc, 141, 2279-2287 (2019)
"De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease.": C. Nitsche; T. Passioura; P. Varava; M.C. Mahawaththa; M.M. Leuthold; C.D. Klein; H. Suga; G. Otting; ACS Med Chem Lett, 10, 168-174 (2019)
"Flexizyme-enabled benchtop biosynthesis of thiopeptides.": S.R. Fleming; T.E. Bartges; A.A. Vinogradov; C.L. Kirkpatrick; Y. Goto; H. Suga; L.M. Hicks; A.A. Bowers; J Am Chem Soc, 141, 758-762 (2019)
"RNA Display Methods for the Discovery of Bioactive Macrocycles.": Y. Huang; M.M. Wiedmann; H. Suga; Chemical reviews, 119, 10360-10391 (2019)

2018年

"Structural Features and Binding Modes of Thioether-Cyclized Peptide Ligands.": M.E. Otero-Ramirez; T. Passioura; H. Suga; Biomedicines, 6, (2018)
"In vitro expression of genetically encoded non-standard peptides consisting of exotic amino acid building blocks.": H. Hirose; C. Tsiamantas; T. Katoh; H. Suga; Curr Opin Biotechnol, 58, 28-36 (2018)
"Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist.": W. Miao; K. Sakai; N. Ozawa; T. Nishiuchi; Y. Suzuki; K. Ito; T. Morioka; M. Umitsu; J. Takagi; H. Suga; K. Matsumoto; Scientific reports, 8, 16492 (2018)
"Pyrrole-Mediated Peptide Cyclization Identified through Genetically Reprogrammed Peptide Synthesis.": K.W. Decoene; W. Vannecke; T. Passioura; H. Suga; A. Madder; Biomedicines, 6, (2018)
"MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner.": W. Miao; K. Sakai; R. Imamura; K. Ito; H. Suga; T. Sakuma; T. Yamamoto; K. Matsumoto; International journal of molecular sciences, 19, (2018)
"Nonproteinogenic deep mutational scanning of linear and cyclic peptides.": J.M. Rogers; T. Passioura; H. Suga; Proc Natl Acad Sci U S A, 115, 10959-10964 (2018)
"Artificial In Vitro Biosynthesis Systems for the Development of Pseudo-Natural Products.": Y. Goto; H. Suga; B Chem Soc Jpn, 91, 410-419 (2018)
"Artificial Division of Codon Boxes for Expansion of the Amino Acid Repertoire of Ribosomal Polypeptide Synthesis.": Y. Iwane; T. Katoh; Y. Goto; H. Suga; Methods Mol Biol, 1728, 17-47 (2018)
"Crystallographic Analysis of MATE-Type Multidrug Exporter with Its Inhibitors.": T. Kusakizako; Y. Tanaka; C.J. Hipolito; H. Suga; O. Nureki; Methods Mol Biol, 1700, 37-57 (2018)
"De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry.": T. Passioura; K. Watashi; K. Fukano; S. Shimura; W. Saso; R. Morishita; Y. Ogasawara; Y. Tanaka; M. Mizokami; C. Sureau; H. Suga; T. Wakita; Cell chemical biology, 25, 906-+ (2018)
"Display Selection of Exotic Macrocyclic Peptides Expressed under a Radically Reprogrammed 23 Amino Acid Genetic Code.": T. Passioura; W. Liu; D. Dunkelmann; T. Higuchi; H. Suga; J Am Chem Soc, 140, 11551-11555 (2018)
"Engineering of RiPP pathways for the production of artificial peptides bearing various non-proteinogenic structures.": Y. Goto; H. Suga; Current opinion in chemical biology, 46, 82-90 (2018)
"Facile Synthesis of Dimeric Thioether-Macrocyclic Peptides with Antibody-like Affinity against Plexin-B1.": N.K. Bashiruddi; U. Matsunaga; M. Nagano; J. Takagi; H. Suga; Bioconjugate Chem, 29, 1847-1851 (2018)
"Genetic code expansion via integration of redundant amino acid assignment by finely tuning tRNA pools.": K. Tajima; T. Katoh; H. Suga; Current opinion in chemical biology, 46, 212-218 (2018)
"Max-Bergmann award lecture:A RaPID way to discover bioactive nonstandard peptides assisted by the flexizyme and FIT systems.": H. Suga; Journal of peptide science : an official publication of the European Peptide Society, 24, (2018)
"Non-competitive cyclic peptides for targeting enzyme-substrate complexes.": T.E. McAllister; T.L. Yeh; M.I. Abboud; I.K.H. Leung; E.S. Hookway; O.N.F. King; B. Bhushan; S.T. Williams; R.J. Hopkinson; M. Munzel; N.D. Loik; R. Chowdhury; U. Oppermann; T.D.W. Claridge; Y. Goto; H. Suga; C.J. Schofield; A. Kawamura; Chemical science, 9, 4569-4578 (2018)
"Quality control by trans-editing factor prevents global mistranslation of non-protein amino acid alpha-aminobutyrate.": J.M. Bacusmo; A.B. Kuzmishin; W.A. Cantara; Y. Goto; H. Suga; K. Musier-Forsyth; RNA Biol, 15, 576-585 (2018)
"Ribosomal Incorporation of Consecutive beta-Amino Acids.": T. Katoh; H. Suga; J Am Chem Soc, 140, 12159-12167 (2018)
"Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids.": J.M. Rogers; S. Kwon; S.J. Dawson; P.K. Mandal; H. Suga; I. Huc; Nature chemistry, 10, 405-412 (2018)
"Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A.": T. Passioura; B. Bhushan; A. Tumber; A. Kawamura; H. Suga; Bioorganic & medicinal chemistry, 26, 1225-1231 (2018)
"Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity.": K. Nishio; R. Belle; T. Katoh; A. Kawamura; T. Sengoku; K. Hanada; N. Ohsawa; M. Shirouzu; S. Yokoyama; H. Suga; Chembiochem, 19, 979-985 (2018)
"tRNA engineering for manipulating genetic code.": T. Katoh; Y. Iwane; H. Suga; RNA Biology, 15, 453-460 (2018)

2017年

"Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporation.": T. Katoh; Y. Iwane; H. Suga; Nucleic Acids Res, 45, 12601-12610 (2017)
"Efficient siRNA Delivery by Lipid Nanoparticles Modified with a Nonstandard Macrocyclic Peptide for EpCAM-Targeting.": Y. Sakurai; W. Mizumura; M. Murata; T. Hada; S. Yamamoto; K. Ito; K. Iwasaki; T. Katoh; Y. Goto; A. Takagi; M. Kohara; H. Suga; H. Harashima; Mol Pharm, 14, 3290-3298 (2017)
"Strategies for transitioning macrocyclic peptides to cell-permeable drug leads.": L.J. Walport; R. Obexer; H. Suga; Curr Opin Biotechnol, 48, 242-250 (2017)
"Conformational and chemical selection by a trans-acting editing domain.": E.M. Danhart; M. Bakhtina; W.A. Cantara; A.B. Kuzmishin; X. Ma; B.L. Sanford; O. Vargas-Rodriguez; M. Kosutic; Y. Goto; H. Suga; K. Nakanishi; R. Micura; M.P. Foster; K. Musier-Forsyth; Proc Natl Acad Sci U S A, 114, E6774-E6783 (2017)
"Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis.": B.S. Shin; T. Katoh; E. Gutierrez; J.R. Kim; H. Suga; T.E. Dever; Nucleic Acids Res, 45, 8392-8402 (2017)
"Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5.": X. Song; L.Y. Lu; T. Passioura; H. Suga; Org Biomol Chem, 15, 5155-5160 (2017)
"Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.": A. Kawamura; M. Munzel; T. Kojima; C. Yapp; B. Bhushan; Y. Goto; A. Tumber; T. Katoh; O.N. King; T. Passioura; L.J. Walport; S.B. Hatch; S. Madden; S. Muller; P.E. Brennan; R. Chowdhury; R.J. Hopkinson; H. Suga; C.J. Schofield; Nature communications, 8, 14773 (2017)
"Exploring sequence space: harnessing chemical and biological diversity towards new peptide leads.": R. Obexer; L.J. Walport; H. Suga; Current opinion in chemical biology, 38, 52-61 (2017)
"Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo.": T. Ozaki; K. Yamashita; Y. Goto; M. Shimomura; S. Hayashi; S. Asamizu; Y. Sugai; H. Ikeda; H. Suga; H. Onaka; Nature communications, 8, 14207 (2017)
"Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases.": H. Yu; P. Dranchak; Z. Li; R. MacArthur; M.S. Munson; N. Mehzabeen; N.J. Baird; K.P. Battalie; D. Ross; S. Lovell; C.K. Carlow; H. Suga; J. Inglese; Nature communications, 8, 14932 (2017)
"Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides.": S.A.K. Jongkees; S. Caner; C. Tysoe; G.D. Brayer; S.G. Withers; H. Suga; Cell chemical biology, 24, 381-390 (2017)
"Consecutive Elongation of D-Amino Acids in Translation.": T. Katoh; K. Tajima; H. Suga; Cell chemical biology, 24, 46-54 (2017)
"A RaPID way to discover nonstandard macrocyclic peptide modulators of drug targets.": T. Passioura; H. Suga; Chemical communications, 53, 1931-1940 (2017)
"In vivo targeting of c-Met using a non-standard macrocyclic peptide in gastric carcinoma.": D.W. Hwang; N. Bahng; K. Ito; S. Ha; M.Y. Kim; E. Lee; H. Suga; D.S. Lee; Cancer letters, 385, 144-149 (2017)
"A Pseudomonas aeruginosa Quorum-Sensing autoinducer analog enhances the activity of antibiotics against resistant strains.": T. Amoh; K. Murakami; R. Kariyama; K. Hori; Y. Irie; D. Viducic; K. Hirota; J. Igarashi; H. Suga; H. Kumon; Y. Miyake; The Journal of Medical Investigation, 64, 101-109 (2017)
"Effects of an autoinducer analogue on antibiotic tolerance in Pseudomonas aeruginosa.": T. Amoh; K. Murakami; R. Kariyama; K. Hori; D. Viducic; K. Hirota; J. Igarashi; H. Suga; M.R. Parsek; H. Kumon; Y. Miyake; J Antimicrob Chemother, 72, 2230-2240 (2017)
"Identification of nonstandard macrocyclic peptide ligands through display screening.": R.D. Taylor; M. Rey-Carrizo; T. Passioura; H. Suga; Drug discovery today. Technologies, 26, 17-23 (2017)

2016年

"Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide.": Y. Matsunaga; N.K. Bashiruddin; Y. Kitago; J. Takagi; H. Suga; Cell chemical biology, 23, 1341-1350 (2016)
"DNA module platform for developing colorimetric aptamer sensors.": Y. Tomita; Y. Morita; H. Suga; D. Fujiwara; BioTechniques, 60, 285-292 (2016)
"Ribosome-mediated synthesis of natural product-like peptides via cell-free translation.": R. Maini; S. Umemoto; H. Suga; Current opinion in chemical biology, 34, 44-52 (2016)
"LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter from Vibrio cholerae.": T. Kusakizako; Y. Tanaka; C.J. Hipolito; T. Kuroda; R. Ishitani; H. Suga; O. Nureki; Acta crystallographica. Section F, Structural biology communications, 72, 552-557 (2016)
"Energetics of side-chain snorkeling in transmembrane helices probed by nonproteinogenic amino acids.": K. Ojemalm; T. Higuchi; P. Lara; E. Lindahl; H. Suga; G. von Heijne; Proc Natl Acad Sci U S A, 113, 10559-10564 (2016)
"A human microRNA precursor binding to folic acid discovered by small RNA transcriptomic SELEX.": N. Terasaka; K. Futai; T. Katoh; H. Suga; RNA, 22, 1918-1928 (2016)
"A Post-translational Cyclodehydratase, PatD, Tolerates Sequence Variation in the C-terminal Region of Substrate Peptides.": Y. Goto; H. Suga; Chem Lett, 45, 1247-1249 (2016)
"Essential structural elements in tRNA(Pro) for EF-P-mediated alleviation of translation stalling.": T. Katoh; I. Wohlgemuth; M. Nagano; M.V. Rodnina; H. Suga; Nature communications, 7, (2016)
"tRid, an enabling method to isolate previously inaccessible small RNA fractions.": K. Futai; N. Terasaka; T. Katoh; H. Suga; Methods, 106, 105-111 (2016)
"Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes.": Y. Iwane; A. Hitomi; H. Murakami; T. Katoh; Y. Goto; H. Suga; Nature chemistry, 8, 317-325 (2016)
"Genetic Code Expansion by Degeneracy Reprogramming of Arginyl Codons.": K.B. Lee; C.Y. Hou; C.E. Kim; D.M. Kim; H. Suga; T.J. Kang; Chembiochem, 17, 1198-1201 (2016)
"Ribosomal Synthesis of Peptides with Multiple beta-Amino Acids.": T. Fujino; Y. Goto; H. Suga; H. Murakami; J Am Chem Soc, 138, 1962-1969 (2016)
"Characterization of the Stereochemical Configuration of Lanthionines Formed by the Lanthipeptide Synthetase GeoM.": N. Garg; Y. Goto; T. Chen; W.A. van der Donk; Biopolymers, 106, 834-842 (2016)
"Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor.": N. Bayo-Puxan; R. Rodriguez-Mias; M. Goldflam; M. Kotev; S. Ciudad; C.J. Hipolito; M. Varese; H. Suga; R. Campos-Olivas; X. Barril; V. Guallar; M. Teixido; J. Garcia; E. Giralt; Chemmedchem, 11, 928-939 (2016)
"The synthesis and structure of a dianionic species with a bond between pentacoordinated tin atoms: bonding properties of the tin-tin bond.": S. Tsukada; N.J. O'Brien; N. Kano; T. Kawashima; J.D. Guo; S. Nagase; Dalton T, 45, 19374-19379 (2016)

2015年

"A Fluorescent Imaging Probe Based on a Macrocyclic Scaffold That Binds to Cellular EpCAM.": K. Iwasaki; Y. Goto; T. Katoh; T. Yamashita; S. Kaneko; H. Suga; J Mol Evol, 81, 210-217 (2015)
"Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming.": J.M. Rogers; H. Suga; Organic & Biomolecular Chemistry, 13, 9353-9363 (2015)
"Synthesis of fused tricyclic peptides using a reprogrammed translation system and chemical modification.": N.K. Bashiruddin; M. Nagano; H. Suga; Bioorg Chem, 61, 45-50 (2015)
"Homologous trans-editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation.": Z.W. Liu; O. Vargas-Rodriguez; Y. Goto; E.M. Novoa; L.R. de Pouplana; H. Suga; K. Musier-Forsyth; P Natl Acad Sci USA, 112, 6027-6032 (2015)
"Recent Developments of Engineered Translational Machineries for the Incorporation of Non-Canonical Amino Acids into Polypeptides.": N. Terasaka; Y. Iwane; A.S. Geiermann; Y. Goto; H. Suga; International journal of molecular sciences, 16, 6513-6531 (2015)
"Artificial human Met agonists based on macrocycle scaffolds.": K. Ito; K. Sakai; Y. Suzuki; N. Ozawa; T. Hatta; T. Natsume; K. Matsumoto; H. Suga; Nature communications, 6, (2015)
"Ancestral AlaX Editing Enzymes for Control of Genetic Code Fidelity Are Not tRNA-specific.": E.M. Novoa; O. Vargas-Rodriguez; S. Lange; Y. Goto; H. Suga; K. Musier-Forsyth; L.R. de Pouplana; J Biol Chem, 290, 10495-10503 (2015)
"Selection-based discovery of macrocyclic peptides for the next generation therapeutics.": T. Morioka; N.D. Loik; C.J. Hipolito; Y. Goto; H. Suga; Current opinion in chemical biology, 26, 34-41 (2015)
"Oxidative Bond Cleavage of the Silicon-Silicon Bond of a Pentacoordinated Disilicate.": N. Kano; H. Miyake; K. Sasaki; T. Kawashima; Heteroatom Chem, 26, 183-186 (2015)
"Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies.": N.K. Bashiruddin; H. Suga; Current opinion in chemical biology, 24, 131-138 (2015)
"Interconversion among Dianionic, Anionic, and Neutral Compounds Bearing a Bond between Two Pentacoordinated Germanium Atoms.": N. Kano; S. Tsukada; Y. Shibata; T. Kawashima; H. Sato; J.D. Guo; S. Nagase; Organometallics, 34, 56-62 (2015)
"2,2 '-Disilylazobenzenes featuring double intramolecular nitrogen center dot center dot center dot silicon coordination: a photoisomerizable fluorophore.": N. Kano; M. Yamamura; T. Kawashima; Dalton T, 44, 16256-16265 (2015)
"Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies.": N.K. Bashiruddin; H. Suga; Current opinion in chemical biology, 24, 131-138 (2015)

2014年

"Reprogramming the genetic code in vitro.": T. Passioura; H. Suga; Trends in biochemical sciences, 39, 400-408 (2014)
"Ribosomal synthesis of an amphotericin-B inspired macrocycle.": K. Torikai; H. Suga; J Am Chem Soc, 136, 17359-17361 (2014)
"Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution.": B.J. Desai; Y. Goto; A. Cembran; A.A. Fedorov; S.C. Almo; J. Gao; H. Suga; J.A. Gerlt; Proc Natl Acad Sci U S A, 111, 15066-15071 (2014)
"ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.": S. Adachi; M. Homoto; R. Tanaka; Y. Hioki; H. Murakami; H. Suga; M. Matsumoto; K.I. Nakayama; T. Hatta; S. Iemura; T. Natsume; Nucleic Acids Res, 42, 10037-10049 (2014)
"Crystallization and preliminary X-ray diffraction analysis of YidC, a membrane-protein chaperone and insertase from Bacillus halodurans.": K. Kumazaki; T. Tsukazaki; T. Nishizawa; Y. Tanaka; H.E. Kato; Y. Nakada-Nakura; K. Hirata; Y. Mori; H. Suga; N. Dohmae; R. Ishitani; O. Nureki; Acta crystallographica. Section F, Structural biology communications, 70, 1056-1060 (2014)
"Arrayed lipid bilayer chambers allow single-molecule analysis of membrane transporter activity.": R. Watanabe; N. Soga; D. Fujita; K.V. Tabata; L. Yamauchi; S. Hyeon Kim; D. Asanuma; M. Kamiya; Y. Urano; H. Suga; H. Noji; Nature communications, 5, 4519 (2014)
"An orthogonal ribosome-tRNA pair via engineering of the peptidyl transferase center.": N. Terasaka; G. Hayashi; T. Katoh; H. Suga; Nat Chem Biol, 10, 555-557 (2014)
"One-pot synthesis of azoline-containing peptides in a cell-free translation system integrated with a posttranslational cyclodehydratase.": Y. Goto; Y. Ito; Y. Kato; S. Tsunoda; H. Suga; Chemistry & biology, 21, 766-774 (2014)
"Flexizymes-facilitated Genetic Code Reprogramming Leading to the Discovery of Drug-like Peptides.": N. Terasaka; H. Suga; Chem Lett, 43, 11-19 (2014)
"Protein cocrystallization molecules originating from in vitro selected macrocyclic peptides.": C.J. Hipolito; N.K. Bashiruddin; H. Suga; Current opinion in structural biology, 26, 24-31 (2014)
"Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets.": T. Shimada; K. Shimada; M. Matsui; Y. Kitai; J. Igarashi; H. Suga; A. Ishihama; Genes to cells : devoted to molecular & cellular mechanisms, 19, 405-418 (2014)
"Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.": A. Kodan; T. Yamaguchi; T. Nakatsu; K. Sakiyama; C.J. Hipolito; A. Fujioka; R. Hirokane; K. Ikeguchi; B. Watanabe; J. Hiratake; Y. Kimura; H. Suga; K. Ueda; H. Kato; Proc Natl Acad Sci U S A, 111, 4049-4054 (2014)
"Selection-based discovery of druglike macrocyclic peptides.": T. Passioura; T. Katoh; Y. Goto; H. Suga; Annual review of biochemistry, 83, 727-752 (2014)
"Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change.": K. Yamagata; Y. Goto; H. Nishimasu; J. Morimoto; R. Ishitani; N. Dohmae; N. Takeda; R. Nagai; I. Komuro; H. Suga; O. Nureki; Structure, 22, 345-352 (2014)
"Distinct tRNA recognition strategies used by a homologous family of editing domains prevent mistranslation.": M. Das; O. Vargas-Rodriguez; Y. Goto; H. Suga; K. Musier-Forsyth; Nucleic Acids Res, 42, 3943-3953 (2014)
"Flexizymes, their evolutionary history and diverse utilities.": T. Passioura; H. Suga; Topics in current chemistry, 344, 331-345 (2014)
"Synthesis, Structure, and Thermolysis of Tetracoordinated 1λ4,2‐Selenazetidines Bearing Two Chiral Centers at the 3‐ and 4‐Positions.": Y. Daicho; N. Kano; M. Yukimoto; M. Minoura; T. Kawashima; Heteroatom Chem, 25, 492-499 (2014)
"Aziridine formation with retention of configuration from a pentacoordinated 1,2-thiazetidine bearing two chiral centers at the 3- and 4-positions.": Y. Daicho; Y. Watanabe; N. Kano; M. Yukimoto; M. Minoura; T. Kawashima; Bull. Chem. Soc. Jpn, 87, (2014)

2013年

"Nonstandard peptide expression under the genetic code consisting of reprogrammed dual sense codons.": Y. Goto; M. Iseki; A. Hitomi; H. Murakami; H. Suga; ACS chemical biology, 8, 2630-2634 (2013)
"A macrocyclic peptide that serves as a cocrystallization ligand and inhibits the function of a MATE family transporter.": C.J. Hipolito; Y. Tanaka; T. Katoh; O. Nureki; H. Suga; Molecules, 18, 10514-10530 (2013)
"Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.": Y. Tanaka; C.J. Hipolito; A.D. Maturana; K. Ito; T. Kuroda; T. Higuchi; T. Katoh; H.E. Kato; M. Hattori; K. Kumazaki; T. Tsukazaki; R. Ishitani; H. Suga; O. Nureki; Nature, 496, 247-251 (2013)
"Flexizyme-mediated genetic reprogramming as a tool for noncanonical peptide synthesis and drug discovery.": T. Passioura; H. Suga; Chemistry, 19, 6530-6536 (2013)
"In vitro selection of multiple libraries created by genetic code reprogramming to discover macrocyclic peptides that antagonize VEGFR2 activity in living cells.": T. Kawakami; T. Ishizawa; T. Fujino; P.C. Reid; H. Suga; H. Murakami; ACS chemical biology, 8, 1205-1214 (2013)
"Technologies for the synthesis of mRNA-encoding libraries and discovery of bioactive natural product-inspired non-traditional macrocyclic peptides.": K. Ito; T. Passioura; H. Suga; Molecules, 18, 3502-3528 (2013)
"Reevaluation of the D-amino acid compatibility with the elongation event in translation.": T. Fujino; Y. Goto; H. Suga; H. Murakami; J Am Chem Soc, 135, 1830-1837 (2013)
"Fluorescent azobenzenes and aromatic aldimines featuring an N-B interaction.": J. Yoshino; N. Kano; T. Kawashima; Dalton Trans, 42, 15826-15834 (2013)
"Synthesis of a phosphine imide bearing a hydrosilane moiety, and its water-driven reduction to a phosphine.": N. Kano; K. Yanaizumi; X. Meng; N. Havare; T. Kawashima; Chemical communications, 49, 10373-10375 (2013)

2012年

"Comparative evaluation of two cell-free protein synthesis systems derived from Escherichia coli for genetic code reprogramming.": K.B. Lee; H.C. Kim; D.M. Kim; T.J. Kang; H. Suga; Journal of biotechnology, 164, 330-335 (2012)
"Novel acridine-based N-acyl-homoserine lactone analogs induce endoreduplication in the human oral squamous carcinoma cell line SAS.": H. Chai; M. Hazawa; Y. Hosokawa; J. Igarashi; H. Suga; I. Kashiwakura; Biological & pharmaceutical bulletin, 35, 1257-1263 (2012)
"Ribosomal production and in vitro selection of natural product-like peptidomimetics: the FIT and RaPID systems.": C.J. Hipolito; H. Suga; Current opinion in chemical biology, 16, 196-203 (2012)
"Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation.": K. Iwasaki; Y. Goto; T. Katoh; H. Suga; Org Biomol Chem, 10, 5783-5786 (2012)
"Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2.": J. Morimoto; Y. Hayashi; H. Suga; Angewandte Chemie, 51, 3423-3427 (2012)
"In vitro selection of anti-Akt2 thioether-macrocyclic peptides leading to isoform-selective inhibitors.": Y. Hayashi; J. Morimoto; H. Suga; ACS chemical biology, 7, 607-613 (2012)
"Flexizymes as a tRNA acylation tool facilitating genetic code reprogramming.": Y. Goto; H. Suga; Methods Mol Biol, 848, 465-478 (2012)
"Charging of tRNAs using ribozymes and selection of cyclic peptides containing thioethers.": P.C. Reid; Y. Goto; T. Katoh; H. Suga; Methods Mol Biol, 805, 335-348 (2012)
"Control of the Equilibrium between 2-Phosphinoazobenzenes and Inner Phosphonium Salts by Heat, Solvent, Acid, and Photoirradiation.": M. Yamamura; N. Kano; T. Kawashima; Bull. Chem. Soc. Jpn, 85, 110-123 (2012)
"2,2'-Diborylazobenzenes with Double N-B Coordination: Control of Fluorescent Properties by Substituents and Redox Reactions.": N. Kano; A. Furuta; T. Kambe; J. Yoshino; Y. Shibata; T. Kawashima; N. Mizorogi; S. Nagase; European Journal of Inorganic Chemistry, 1584-1587 (2012)
"Synthesis and Properties of Water-soluble Fluorescent 2-Borylazobenzenes Bearing Ionic Functional Groups.": H. Itoi; T. Kambe; N. Kano; T. Kawashima; Inorganica Chimica Acta, 381, 117-123 (2012)
"Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562.": M. Hazawa; M. Kudo; T. Iwata; K. Saito; K. Takahashi; J. Igarashi; H. Suga; I. Kashiwakura; Investigational new drugs, 30, 862-869 (2012)
"Functional properties of synthetic N-acyl-L-homoserine lactone analogs of quorum-sensing gram-negative bacteria on the growth of human oral squamous carcinoma cells.": H. Chai; M. Hazawa; N. Shirai; J. Igarashi; K. Takahashi; Y. Hosokawa; H. Suga; I. Kashiwakura; Investigational new drugs, 30, 157-163 (2012)

2011年

"Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library.": Y. Yamagishi; I. Shoji; S. Miyagawa; T. Kawakami; T. Katoh; Y. Goto; H. Suga; Chemistry & biology, 18, 1562-1570 (2011)
"The RNA origin of transfer RNA aminoacylation and beyond.": H. Suga; G. Hayashi; N. Terasaka; Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 366, 2959-2964 (2011)
"Ribosomal synthesis of backbone macrocyclic peptides.": T. Katoh; Y. Goto; M.S. Reza; H. Suga; Chemical communications, 47, 9946-9958 (2011)
"Flexizymes: their evolutionary history and the origin of catalytic function.": J. Morimoto; Y. Hayashi; K. Iwasaki; H. Suga; Accounts of chemical research, 44, 1359-1368 (2011)
"Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase.": J. Chung; E. Goo; S. Yu; O. Choi; J. Lee; J. Kim; H. Kim; J. Igarashi; H. Suga; J.S. Moon; I. Hwang; S. Rhee; Proc Natl Acad Sci U S A, 108, 12089-12094 (2011)
"Flexizymes for genetic code reprogramming.": Y. Goto; T. Katoh; H. Suga; Nature protocols, 6, 779-790 (2011)
"Formation of a Cyclic Bis(iminophosphorane) from a 2,2'-Bis(phosphino)azobenzene via N=N Bond Cleavage.": M. Yamamura; N. Kano; T. Kawashima; Heteroatom Chem, 22, 301-306 (2011)
"Isolation of a Metastable Geometrical Isomer of a Hexacoordinated Dihydrophosphate: Elucidation of Its Enhanced Reactivity in Umpolung of a Hydrogen Atom of Water.": H. Miyake; N. Kano; T. Kawashima; Inorganic Chemistry, 50, 9083-9089 (2011)
"Translation of a histone H3 tail as a model system for studying peptidyl-tRNA drop-off.": T.J. Kang; H. Suga; FEBS letters, 585, 2269-2274 (2011)
"Apolar surface area determines the efficiency of translocon-mediated membrane-protein integration into the endoplasmic reticulum.": K. Ojemalm; T. Higuchi; Y. Jiang; U. Langel; I. Nilsson; S.H. White; H. Suga; G. von Heijne; Proc Natl Acad Sci U S A, 108, E359-364 (2011)
"Ribosomal synthesis of backbone-macrocyclic peptides containing gamma-amino acids.": Y. Ohshiro; E. Nakajima; Y. Goto; S. Fuse; T. Takahashi; T. Doi; H. Suga; Chembiochem, 12, 1183-1187 (2011)
"Synthesis of the backbone cyclic peptide sunflower trypsin inhibitor-1 promoted by the induced peptidyl-tRNA drop-off.": T.J. Kang; Y. Hayashi; H. Suga; Angewandte Chemie, 50, 2159-2161 (2011)
"Custom synthesis of autoinducers and their analogues.": J. Igarashi; H. Suga; Methods Mol Biol, 692, 265-274 (2011)

2010年

"Ribosome evolution for two artificial amino acids in E. coli.": G. Hayashi; Y. Goto; H. Suga; Chemistry & biology, 17, 320-321 (2010)
"Engineering of the Redox Ribozyme for the Determination of Its Architecture.": S.B. Pattnaik; K. Jin; K. Futai; H. Suga; Chem Lett, 39, 786-787 (2010)

2009年

"Diverse backbone-cyclized peptides via codon reprogramming.": T. Kawakami; A. Ohta; M. Ohuchi; H. Ashigai; H. Murakami; H. Suga; Nat Chem Biol, 5, 888-890 (2009)
"A flexizyme that selectively charges amino acids activated by a water-friendly leaving group.": N. Niwa; Y. Yamagishi; H. Murakami; H. Suga; Bioorganic & medicinal chemistry letters, 19, 3892-3894 (2009)
"Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides.": Y. Goto; K. Iwasaki; K. Torikai; H. Murakami; H. Suga; Chemical communications, 3419-3421 (2009)
"Ribosomal synthesis of cyclic peptides with a fluorogenic oxidative coupling reaction.": Y. Yamagishi; H. Ashigai; Y. Goto; H. Murakami; H. Suga; Chembiochem, 10, 1469-1472 (2009)
"Ribosomal synthesis of peptides with C-terminal lactams, thiolactones, and alkylamides.": E. Nakajima; Y. Goto; Y. Sako; H. Murakami; H. Suga; Chembiochem, 10, 1186-1192 (2009)
"Translation initiation with initiator tRNA charged with exotic peptides.": Y. Goto; H. Suga; J Am Chem Soc, 131, 5040-5041 (2009)
"Bases in the anticodon loop of tRNA(Ala)(GGC) prevent misreading.": H. Murakami; A. Ohta; H. Suga; Nature structural & molecular biology, 16, 353-358 (2009)

2008年

"Ribosomal synthesis of polypeptoids and peptoid-peptide hybrids.": T. Kawakami; H. Murakami; H. Suga; J Am Chem Soc, 130, 16861-16863 (2008)
"Expression of histone H3 tails with combinatorial lysine modifications under the reprogrammed genetic code for the investigation on epigenetic markers.": T.J. Kang; S. Yuzawa; H. Suga; Chemistry & biology, 15, 1166-1174 (2008)
"Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme.": H. Xiao; H. Murakami; H. Suga; A.R. Ferre-D'Amare; Nature, 454, 358-361 (2008)
"Initiating translation with D-amino acids.": Y. Goto; H. Murakami; H. Suga; Rna, 14, 1390-1398 (2008)
"Ribosomal synthesis of bicyclic peptides via two orthogonal inter-side-chain reactions.": Y. Sako; J. Morimoto; H. Murakami; H. Suga; J Am Chem Soc, 130, 7232-7234 (2008)
"Ribosomal synthesis of peptidase-resistant peptides closed by a nonreducible inter-side-chain bond.": Y. Sako; Y. Goto; H. Murakami; H. Suga; ACS chemical biology, 3, 241-249 (2008)
"Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides.": Y. Goto; A. Ohta; Y. Sako; Y. Yamagishi; H. Murakami; H. Suga; ACS chemical biology, 3, 120-129 (2008)
"Messenger RNA-programmed incorporation of multiple N-methyl-amino acids into linear and cyclic peptides.": T. Kawakami; H. Murakami; H. Suga; Chemistry & biology, 15, 32-42 (2008)
"Ribosomal synthesis of nonstandard peptides.": T.J. Kang; H. Suga; Biochemistry and cell biology = Biochimie et biologie cellulaire, 86, 92-99 (2008)
"Polymerization of alpha-hydroxy acids by ribosomes.": A. Ohta; H. Murakami; H. Suga; Chembiochem, 9, 2773-2778 (2008)
"Synthesis of biopolymers using genetic code reprogramming.": A. Ohta; Y. Yamagishi; H. Suga; Current opinion in chemical biology, 12, 159-167 (2008)

2007年以前

"Electronic Excitation Energy Transfer in DNA. Nature of Triplet Excitations Capturing Centers": V.M. Yashchuk, V. Y. Kudrya, M. Y. Losytskyy, I. Y. Dubey, H. Suga*; Molecular Crystals and Liquid Crystals 467, 311-323. (2007)
"Synthetic and Biological Functional Compounds with Direct Excitons Conductivity for Nanoelectronic Devices": Valeriy M. Yashchuk; Vladislav Yu. Kudrya; Irina V. Savchenko; Grygoriy P. Golovach; Igor Ya. Dubey; Rostyslav D. Fedorovich; Hiroaki Suga; Juozas V. Grazulevicius; Molecular Crystals and Liquid Crystals, 1563-5287, Volume 468, 2007, Pages 275/[627] – 288/[640]
"Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump": Y.Y. Chan, H.S. Bian, T.M. Tan, M.E. Mattmann, G.D. Geske, J. Igarashi, T. Hatano, H. Suga, H.E. Blackwell, K.L. Chua; Journal of Bacteriology 189, 4320-4324 (2007)
"Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae": J. Kim, Y. Kang, O. Choi, Y. Jeong, J.E. Jeong, J.Y. Lim, M. Kim, J.S. Moon, H. Suga, I. Hwang; Molecular Microbiology 64, 165-179 (2007)
"N-(3-hydroxyhexanoyl)-l-homoserine lactone is the biologically relevant quormone that regulates the phz operon of Pseudomonas chlororaphis strain 30-84": S. R. Khan, J. Herman, J. Krank, N. J. Serkova, M. E. Churchill, H. Suga, S. K. Farrand; Applied Environmental Microbiology 73(22), 7443-7455.(2007)
"Synthesis of polyester by means of genetic code reprogramming": A. Ohta, H. Murakami, E. Higashimura, H. Suga*; Chemistry & Biology 14, 1315-1322 (2007)
"The flexizyme system: A highly flexible tRNA aminoacyation tool for the translation apparatus": M. Ohuchi, H. Murakami, H. Suga*; Current Opinion in Chemical Biology 11, 135-144 (2007)
"The nature of the electronic excitations capturing centres in the DNA": V.M. Yashchuk, V. Y. Kudrya, M. Y. Losytskyy, H. Suga, T. Ohul'chanskyy (2006); Journal of Molecular Liquids 127, 79–83.
"Leucyl/Phenylalanyl-tRNA-protein transferase-mediated chemoenzymatic coupling of N-terminal Arg/Lys units in post-translationally processed proteins with non-natural amino acids": Taki M, Kuno A, Matoba S, Kobayashi Y, Futami J, Murakami H, Suga H, Taira K, Hasegawa T, Sisido; M. ChemBioChem 7, 1676-1679 (2006).
"A highly flexible tRNA acylation method for nonnatural polypeptide synthesis": H. Murakami, A. Ohta, H. Ashigai, H. Suga* (2006); Nature Methods 3, 357-359.
"Stereoisomers of P. aeruginosa autoinducer Analog to probe the regulator binding site": G. Jog, J. Igarashi, H. Suga* (2006); Chemistry & Biology 13, 123-128.
"Activation of the phz operon of Pseudomonas fluorescens 2-79 requires the LuxR homolog PhzR, N-(3-OH-Hexanoyl)-L-homoserine lactone produced by the LuxI homolog PhzI, and a cis-acting phz box": S.R. Khan, D.V. Mavrodi, G.J. Jog, H. Suga, L.S. Thomashow, S.K. Farrand (2005); Journal of Bacteriology 187, 6517-6527.
"Programmable ribozymes for mischarging tRNA with nonnatural amino acids and their applications to translation": D. Kourouklis, H. Murakami, H. Suga* (2005); Methods, 36(3), 239-244.
"Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae": J. Kim, J.-G. Kim, Y. Kang, J. Y. Jang, G. J. Jog, J. Y. Lim, S. Kim, H. Suga, T. Nagamatsu and I. Hwang (2004); Molecular Microbiology 54, 921-934.
"Designer ribozymes: Programming tRNA specificity into Flexizyme": K. Ramaswamy, H. Saito, H. Murakami, K. Shiba, H. Suga* (2004); Journal of American Chemical Society 126, 11454-11455.
"Reduction of an aldehyde by a NADH/Zn2+-dependent redox active ribozyme": S. Tsukiji, S. Pattnaik, H. Suga* (2004); Journal of American Chemical Society 126, 5044-5045.
"Ribozymes that use redox cofactors": S. Tsukiji, K. Ramaswamy, H. Suga* (2004); Pure & Applied Chemistry 76, 1525-1536.
"Using a solid-phase ribozyme aminoacylation system to reprogram the genetic code": H. Murakami, D. Kourouklis, H. Suga* (2003); Chemistry & Biology 10, 1077-1084.
"An alcohol dehydrogenase ribozyme": S. Tsukiji, S. B. Pattnaik, H. Suga* (2003) "; Nature Structural Biology 10, 713-717.
"A versatile tRNA aminoacylation catalyst based on RNA": A H. Murakami, H. Saito, H. Suga* (2003); Chemistry & Biology 10, 655-662
"Library screening for synthetic agonists and antagonists of Pseudomonas aeruginosa autoinudcer": K. Smith, Y. Bu, H. Suga* (2003); Chemistry & Biology 10, 563-571.
E "Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs": K. Smith, Y. Bu, H. Suga* (2003); Chemistry & Biology 10, 81-89.
"Molecular mechanisms of bacterial quorum sensing as a new drug target": H. Suga* and K. M. Smith (2003); Current Opinion in Chemical Biology 7, 589-591.
"Mechanistic studies on acyl transferase ribozymes and beyond": D. Hodgson, H. Suga* (2003); Biopolymers 10, 1077-1084.
"Outersphere and innersphere coordinated metal ions in an aminoacyl-tRNA synthetase ribozyme": H. Saito, H. Suga* (2002); Nucleic Acid Research 30, 5151-5159.
A "A tRNA aminoacylation system for non-natural amino acids based on a programmable ribozyme": Y. Bessho, D. Hodgson, H. Suga* (2002); Nature Biotechnology 20, 723-728.
"Aminoacyl-tRNA synthesis by a resin-immobilized ribozyme": H. Murakami, N. J. Bonzagni, H. Suga* (2002); Journal of American Chemical Society 124, 6834-6835.
"Minihelix-loop RNAs: Minimal structure for the emergence of a primitive aminoacylation system": K. Ramaswarmy, K. Wei, H. Suga* (2002); Nucleic Acid Research 30, 2162-2171.
"Recognition of Phosphate and Sugar Groups in tRNACys for Aminoacylation: Evolution from E. coli to Human": X. Ming, K. Smith, H. Suga, and Y.-M. Hou (2002); Journal of Molecular Biology 318, 1207-20.
"Concurrent molecular recognition of the amino acid and tRNA by a ribozyme": H. Saito, K. Watanabe, H. Suga* (2001); RNA 7,1867-1878.
"A single metal ion plays structural and chemical roles in an acyl-transferase ribozyme": A. Flynn-Charlebois, N. Lee, H. Suga* (2001); Biochemistry 40, 13623-13632.
"Essential roles of inner-sphere metal ions for the formation of the glutamine binding site in a bifunctional ribozyme": N. Lee, H. Suga* (2001); Biochemistry 40, 13633-13643.
"A ribozyme aminoacylates exclusively on the 3'-hydroxyl group of the 3'-terminus of tRNA": H. Saito, H. Suga* (2001); Journal of American Chemical Society 123, 7178-7179.
"Diverse roles of metal ions in acyl-transferase ribozymes": A. Vaidya, H. Suga* (2001); Biochemistry 40, 7200-7210.
"A mini-helix-loop RNA acts as a trans-acting aminoacylation catalyst": N. Lee, H. Suga* (2001); RNA 7, 1043-1051.
"An In vitro evolved precursor tRNA with aminoacylation activity": H. Saito, D. Kourouklis, H. Suga* (2001); EMBO Journal 20, 1797-1806.
"Ribozyme-catalyzed tRNA aminoacylation": N. Lee, Y. Bessho, K. Wei, J.W. Szostak, H. Suga* (2000); Nature Structural Biology 7, 28-34.
"Unusual Metal Ion Catalysis in an Acyl-Transferase Ribozyme": H. Suga, J.A. Cowan, J.W. Szostak (1998); Biochemistry 37, 10118-10125.
"The Secondary Structure and Essential Catalytic Features of an Acyl Transferase Ribozyme": H. Suga, P.A. Lohse, J.W. Szostak (1998); Journal of American Chemical Society 120, 1151-1156.
"Electrogeneration of Triphenyltin Radical, Anion, and Cation. Electrochemical Initiation of Tin Hydride-Promoted Radical Chain Reactions": H. Tanaka, H. Ogawa, H. Suga, S. Torii, A. Jutand, S. Aziz, A.G. Suarez, C. Amatore; Journal of Organic
"Catalytic antibodies generated via homologous and heterologous immunization": T. Tsumuraya, H. Suga, S. Meguro, A. Tsunakawa, S. Masamune (1995); Journal of American Chemical Society 117, 11390-11396.
"Glycosidase antibodies induced to a half-chair transition-state analog": H. Suga, N. Tanimoto, A.J. Sinskey, S. Masamune (1994); Journal of American Chemical Society 116, 11197-11198.
"Catalytic antibodies generated via heterologous immunization": H. Suga, O. Ersoy, S.F. Williams, T. Tsumuraya, M.N. Margolies, A.J. Sinskey, S. Masamune (1994); Journal of American Chemical Society 116, 6025-6026.
"Catalytic antibodies generated via heterologous immunization": H. Suga, O. Ersoy, T. Tsumuraya, J. Lee, A.J. Sinskey, S. Masamune (1994); Journal of American Chemical Society 116, 487-494.
"Electrooxidative initiation of tin hydride-promoted radical chain reactions": H. Tanaka, H. Suga, H. Ogawa, A.K.M. Abdul Hai, S. Torii, A. Jutand, C. Amatore (1992); Tetrahedron Letters 33, 6495-6498.
"Vicinal bromofluoroalkanes: their regioselective formation and their conversion to fluoroolefins": H. Suga, T. Hamatani, Y. Guggisberg, M. Schlosser (1990); Tetrahedron 46, 4255-4260.
"α-Fluoro- and α,α-difluoroalkanals by substitution of vicinal bromofluoroalkanes and subsequent pummerer rearrangement": H. Suga, M. Schlosser (1990); Tetrahedron 46, 4261-4264.
"Regioselective formation of fluorohydrins and their stereoselective conversion to fluoroolefins": H. Suga, T. Hamatani, M. Schlosser (1990); Tetrahedron 46, 4247-4254.