Xiyun Ye

Postdoctoral researcher

City/country of origin

Shenzhen/China

Hobbies

Running, piano, hiking, and reading

Places You Like

Ocean beach

Where for a big vacation

Iceland/Hawaii/Swiss

Music: what is some intense music for intense lab work?

kpop/Remix/Mendelssohn

What are people in the lab doing?

pipetting

What was surprising about the suga lab

So many instruments

Original motivation towards science?

Curiosity

A few words for future lab mates

Have fun :D

Science is…….

Challenging and fun

Education & professional career

2018-2023

Massachusetts Institute of Technology- PhD

2016-2017

University of Chicago

2014-2018

University of Hong Kong

Publications

"Ribosomal Elongation of Trans-4-Aminocrotonic Acids into Nascent Peptide Chain."

X. Ye; A. Beattie; H. Suga

J Am Chem Soc, 147, 42894-42900 (2025)

"Reversibly Reactive Affinity Selection-Mass Spectrometry Enables Identification of Covalent Peptide Binders."

P. Zhang; X. Ye; J.C.K. Wang; H.T. Baddock; Z. Jensvold; I.T. Foe; A. Loas; D.L. Eaton; Q. Hao; A.H. Nile; B.L. Pentelute

J Am Chem Soc, 146, 15627-15639 (2024)

"Development of an alpha-Klotho Recognizing High-Affinity Peptide Probe from In-Solution Enrichment."

P. Zhang; X. Ye; J.C.K. Wang; C.L. Smith; S. Sousa; A. Loas; D.L. Eaton; M. Preciado Lopez; B.L. Pentelute

JACS Au, 4, 1334-1344 (2024)

"Branched Multimeric Peptides as Affinity Reagents for the Detection of alpha-Klotho Protein."

X. Ye; P. Zhang; J.C.K. Wang; C.L. Smith; S. Sousa; A. Loas; D.L. Eaton; M. Preciado Lopez; B.L. Pentelute

Angew Chem Int Ed Engl, 62, e202300289 (2023)

"Binary combinatorial scanning reveals potent poly-alanine-substituted inhibitors of protein-protein interactions."

X. Ye; Y.C. Lee; Z.P. Gates; Y. Ling; J.C. Mortensen; F.S. Yang; Y.S. Lin; B.L. Pentelute

Commun Chem, 5, 128 (2022)

"De Novo Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein."

S. Pomplun; M. Jbara; A.J. Quartararo; G. Zhang; J.S. Brown; Y.C. Lee; X. Ye; S. Hanna; B.L. Pentelute

ACS Cent Sci, 7, 156-163 (2021)

"Synthesis of proteins by automated flow chemistry."

N. Hartrampf; A. Saebi; M. Poskus; Z.P. Gates; A.J. Callahan; A.E. Cowfer; S. Hanna; S. Antilla; C.K. Schissel; A.J. Quartararo; X. Ye; A.J. Mijalis; M.D. Simon; A. Loas; S. Liu; C. Jessen; T.E. Nielsen; B.L. Pentelute

Science, 368, 980-987 (2020)

"Ultra-large chemical libraries for the discovery of high-affinity peptide binders."

A.J. Quartararo; Z.P. Gates; B.A. Somsen; N. Hartrampf; X. Ye; A. Shimada; Y. Kajihara; C. Ottmann; B.L. Pentelute

Nat Commun, 11, 3183 (2020)

Contact info

• • E-mail… xiyunye"at"g.ecc.u-tokyo.ac.jp (change "at" to @)