Richaud Alexis

Postdoctoral Fellow

City/country of origin

Saint Etienne/France

Hobbies

Practicing sports including Judo and Rock climbing/Bouldering and Canyoning. Drawing art. Learning more about Japanese language, culture and cooking.

Places You Like

Mountain, canyons, and wild forest. Game centers.

Where for a big vacation

In France of course!

What are your strong points?

Organization, solving others problems, repairing stuff

Music: what is some intense music for intense lab work?

“Number One” – Shirō Sagisu (Bleach OST)

What are people in the lab doing?

Challenging the understanding

What was surprising about the suga lab

There is a mecha in the lab!

Original motivation towards science?

I am just trying to understand how everything works

A few words for future lab mates

“Plus on est de fous, plus on rit”

Science is…….

in each of us

Education & professional career

2009-2012

Claude Fauriel Prep School, Math, Physics, Chemistry and Engineer Sciences (France)

2012-2015

Master's program in Materials Chemistry, Organic Chemistry and Chemical Engineering for industrial application, Sigma Clermont Engineering School (France)

2015

Master's program in Organic synthesis and Biocatalysis, Blaise Pascal University (France)

2017-2023

Ph. D. Department of Chemistry and Biochemistry, Florida Atlantic University (Prof. Stéphane Roche)

2023-2025

Postdoctoral Researcher, The University of Tokyo (Prof. Hiroaki Suga)

Publications

"De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics."

G. Zhao; A.D. Richaud; R.T. Williamson; M. Feig; S.P. Roche

ACS Chem Biol, 19, 1583-1592 (2024)

"A platform of ADAPTive scaffolds: development of CDR-H3 beta-hairpin mimics into covalent inhibitors of the PD1/PDL1 immune checkpoint."

S.H. Naylon; A.D. Richaud; G. Zhao; L. Bui; C.P. Dufresne; C.J. Wu; M. Wangpaichitr; N. Savaraj; S.P. Roche

RSC Chem Biol, 5, 1259-1270 (2024)

"Tunable CH/pi Interactions within a Tryptophan Zipper Motif to Stabilize the Fold of Long beta-Hairpin Peptides."

A.D. Richaud; S. Mandal; A. Das; S.P. Roche

ACS Chem Biol, 18, 2555-2563 (2023)

"Passive Membrane Permeability of Sizable Acyclic β-Hairpin Peptides."

J. Moxam; S. Naylon; A.D. Richaud; G. Zhao; A. Padilla; S.P. Roche

ACS Medicinal Chemistry Letters, 14, 278-284 (2023)

"Structure–Property Relationship Study of N-(Hydroxy)Peptides for the Design of Self-Assembled Parallel β-Sheets."

A.D. Richaud; S.P. Roche

The Journal of Organic Chemistry, 85, 12329-12342 (2020)

"Exploiting the Innate Plasticity of the Programmed Cell Death-1 (PD1) Receptor to Design Pembrolizumab H3 Loop Mimics**."

A.D. Richaud; M. Zaghouani; G. Zhao; M. Wangpaichitr; N. Savaraj; S.P. Roche

ChemBioChem, 23, e202200449 (2022)

"Folding in Place: Design of β-Strap Motifs to Stabilize the Folding of Hairpins with Long Loops."

A.D. Richaud; G. Zhao; S. Hobloss; S.P. Roche

The Journal of Organic Chemistry, 86, 13535-13547 (2021)

"Intercepted-Knoevenagel condensation for the synthesis of unsymmetrical fused-tricyclic 4H-pyrans."

C. Shearer; O. Desaunay; S. Zorc; A.D. Richaud; S.S. Samanta; N. Jeedimalla; S.P. Roche

Tetrahedron, 75, 130606 (2019)

Contact info

• • E-mail… arichaud"at"g.ecc.u-tokyo.ac.jp (change "at" to @)